projects
Summary of innovative projects in structural biology and drug discovery, advancing treatments for cancer, immunological disorders, virology, and antibiotic resistance. My work exemplifies the fusion of cutting-edge science with practical applications in medicine and biotechnology
- Scientific Leadership: Delivered structural insights for over 10 oncology drug discovery programs, driving innovation in targeting FGFR, CDK2, and KRAS mutations
- Collaborative Expertise: Acted as a liaison between multidisciplinary teams, including biologists, chemists, and computational scientists, ensuring seamless communication and integration of objectives
- Project Management: Successfully developed and executed project plans addressing critical biological problems, leveraging AI and data analysis tools to streamline workflows
- Technological Prowess: Championed automation in structural biology workflows and adopted CryoEM/X-ray crystallography technologies to enhance drug design processes
- Mentorship: Provided guidance to junior researchers and project teams, fostering a culture of scientific excellence and innovation
| Project | Description | Key Skills |
|---|---|---|
| Recent personal projects using AI | Protein structure prediction and analysis | Alphafold, RFdiffusion and ProteinMPNN |
| FGFR Inhibitors for Cancer Treatment | Discovered selective inhibitors targeting FGFR signaling, implicated in cancers like cholangiocarcinoma and bladder cancer. | Drug Design, Structural Biology |
| CDK2 Inhibitors Development | Developed selective inhibitors for CDK2, a key cell cycle regulator involved in various cancers. | Medicinal Chemistry, Protein Crystallography |
| KRAS G12D Inhibitor Discovery | Identified INCB159020, an orally bioavailable inhibitor for KRAS-driven cancers. | Structure-Based Drug Design (SBDD) |
| N/A | Established automated platforms to accelerate structure-based drug design initiatives. | CryoEM, Laboratory Automation |
| Protein-Ligand Crystal Validation | Enhanced reliability in drug discovery by validating protein-ligand models. | Data Analysis, Protein Crystallography |
| Crystal Harvesting Automation | Developed robotics to automate fragile protein crystal harvesting processes. | Robotics, Computer Vision |
| Antibiotic Resistance Research | Mentored students in designing new antibiotics to combat resistance threats. | Mentoring, Protein Characterization |