projects
I have worked on many innovative projects in structural biology and drug discovery, advancing treatments for cancer, immunological disorders, virology, and antibiotic resistance. My work exemplifies the fusion of cutting-edge science with practical applications in medicine and biotechnology
- Scientific Leadership: Delivered structural insights for over 10 oncology drug discovery programs, driving innovation in targeting FGFR, CDK2, and KRAS mutations
- Collaborative Expertise: Acted as a liaison between multidisciplinary teams, including biologists, chemists, and computational scientists, ensuring seamless communication and integration of objectives
- Project Management: Successfully developed and executed project plans addressing critical biological problems, leveraging AI and data analysis tools to streamline workflows
- Technological Prowess: Championed automation in structural biology workflows and adopted CryoEM/X-ray crystallography technologies to enhance drug design processes
- Mentorship: Provided guidance to junior researchers and project teams, fostering a culture of scientific excellence and innovation
| Project Title | Description | Key Skills | Source Link |
|---|---|---|---|
| FGFR Inhibitors for Cancer Treatment | Discovered selective inhibitors targeting FGFR signaling, implicated in cancers like cholangiocarcinoma and bladder cancer. | Drug Design, Structural Biology | Link |
| CDK2 Inhibitors Development | Developed selective inhibitors for CDK2, a key cell cycle regulator involved in various cancers. | Medicinal Chemistry, Protein Crystallography | Link |
| KRAS G12D Inhibitor Discovery | Identified INCB159020, an orally bioavailable inhibitor for KRAS-driven cancers. | Structure-Based Drug Design (SBDD) | Link |
| CryoEM & X-ray Crystallography Platforms | Established automated platforms to accelerate structure-based drug design initiatives. | CryoEM, Laboratory Automation | N/A |
| Protein-Ligand Crystal Validation | Enhanced reliability in drug discovery by validating protein-ligand models. | Data Analysis, Protein Crystallography | Link |
| Crystal Harvesting Automation | Developed robotics to automate fragile protein crystal harvesting processes. | Robotics, Computer Vision | Link |
| Antibiotic Resistance Research | Mentored students in designing new antibiotics to combat resistance threats. | Mentoring, Protein Characterization | Link |