publications
My top-cited papers showcase groundbreaking advancements in structural biology, medicinal chemistry, and immunology. They highlight my expertise in designing key experiments, solving complex biological problems, and mentoring teams. Covering topics like drug discovery, protein stability, and vaccine design, these studies reflect global collaboration and drive innovation across disciplines.
- KRAS Inhibitors: Development of novel inhibitors targeting KRAS G12D mutations—key breakthroughs in cancer therapy
- Drug Discovery Innovations: Research on inhibitors for CDK2 and FGFR2/3 proteins for new therapeutics for rare disease
- Novel structural Insights: Contributions to polyketide synthase functionality provide critical knowledge applicable to AI-driven enzyme modeling
- HIV Vaccine Design: Research on gp120 glycans addresses immune vulnerabilities—a testament to collaborative problem-solving
- Link to Google Scholar
| Rank | Title | Authors | Publication | Year | Publisher | Link |
|---|---|---|---|---|---|---|
| 1 | Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor | Ye, Qinda; Shvartsbart, Artem; Li, Zhenwu; et al. | Journal of Medicinal Chemistry | 2025 | American Chemical Society | Link |
| 2 | INCB161734: A novel, potent, and orally bioavailable KRAS G12D selective inhibitor | Farren, Matthew R; Roman, Valerie; Gallion, Alexandra; et al. | Cancer Res. | 2024 | N/A | Link |
| 3 | Discovery of (4-pyrazolyl)-2-aminopyrimidines as potent and selective inhibitors of CDK2 | Hummel, Joshua R; Xiao, Kai-Jiong; Yang, Jeffrey C; et al. | Journal of Medicinal Chemistry | 2024 | American Chemical Society | Link |
| 4 | Discovery of potent and selective inhibitors of FGFR2/3 | Shvartsbart, Artem; Roach, Jeremy J; Witten, Michael R; et al. | Journal of Medicinal Chemistry | 2022 | American Chemical Society | Link |
| 5 | Structure–function analysis of the extended conformation of a polyketide synthase module | Li, Xiuyuan; Sevillano, Natalia; La Greca, Florencia; et al. | Journal of the American Chemical Society | 2018 | American Chemical Society | Link |
| 6 | Lipid interactions and angle of approach to the HIV-1 viral membrane | Irimia, Adriana; Serra, Andreia M; Sarkar, Anita; et al. | PLoS Pathogens | 2017 | Public Library of Science | Link |
| 7 | Validation of Protein–Ligand Crystal Structure Models | Pozharski, Edwin; Deller, Marc C; Rupp, Bernhard | Protein Crystallography: Methods and Protocols | 2017 | Springer New York | Link |
| 8 | The role of the secondary coordination sphere in a fungal polysaccharide monooxygenase | Span, Elise A; Suess, Daniel LM; Deller, Marc C; et al. | ACS Chemical Biology | 2017 | American Chemical Society | Link |
| 9 | Key gp120 glycans pose roadblocks to rapid development of VRC01-class antibodies | Kong, Leopold; Ju, Bin; Chen, Yajing; et al. | Immunity | 2016 | Elsevier | Link |
| 10 | Protein stability: a crystallographer's perspective | Deller, Marc C; Kong, Leopold; Rupp, Bernhard | Structural Biology and Crystallization Communications | 2016 | International Union of Crystallography | Link |