My publication Highlights

60+ top-cited peer-reviewed manuscripts showcase groundbreaking advancements in structural biology, medicinal chemistry, and immunology. They highlight my expertise in designing key experiments, solving complex biological problems, and mentoring teams. Covering topics like drug discovery, protein stability, and vaccine design, these studies reflect global collaboration and drive innovation across disciplines.

  • KRAS Inhibitors: Development of novel inhibitors targeting KRAS G12D mutations—key breakthroughs in cancer therapy
  • Drug Discovery Innovations: Research on inhibitors for CDK2 and FGFR2/3 proteins for new therapeutics for rare disease
  • Novel structural Insights: Contributions to polyketide synthase functionality provide critical knowledge applicable to AI-driven enzyme modeling
  • HIV Vaccine Design: Research on gp120 glycans addresses immune vulnerabilities—a testament to collaborative problem-solving
Recent PapersYearAuthorsPublication
Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor2025Ye, Qinda; Shvartsbart, Artem; Li, Zhenwu; et al.Journal of Medicinal Chemistry
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective CDK2 Inhibitors2024Hummel, Joshua R; Xiao, Kai-Jiong; Yang, Jeffrey C; et al.Journal of Medicinal Chemistry
Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant FGFR2/32022Shvartsbart, Artem; Roach, Jeremy J; Witten, Michael R; et al.Journal of Medicinal Chemistry
Structure–function analysis of the extended conformation of a polyketide synthase module2018Li, Xiuyuan; Sevillano, Natalia; La Greca, Florencia; et al.Journal of the American Chemical Society
Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design2017Irimia, Adriana; Serra, Andreia M; Sarkar, Anita; et al.PLoS Pathogens
Validation of Protein–Ligand Crystal Structure Models: Small Molecule and Peptide Ligands2017Pozharski, Edwin; Deller, Marc C; Rupp, BernhardProtein Crystallography: Methods and Protocols
The Role of the Secondary Coordination Sphere in a Fungal Polysaccharide Monooxygenase2017Span, Elise A; Suess, Daniel LM; Deller, Marc C; et al.ACS Chemical Biology
Key gp120 glycans pose roadblocks to the rapid development of VRC01-class antibodies in an HIV-1- infected Chinese donor2016Kong, Leopold; Ju, Bin; Chen, Yajing; et al.Immunity
Protein stability: a crystallographer’s perspective2016Deller, Marc C; Kong, Leopold; Rupp, BernhardStructural Biology and Crystallization Communications
Crystal structure of a two-subunit TrkA octameric gating ring assembly2015Marc C. Deller , Hope A. Johnson, Mitchell D. Miller, Glen Spraggon, Marc-André Elsliger, Ian A. Wilson, et al.PLOS One
Approaches to automated protein crystal harvesting2014Marc C. Deller and Bernhard Rupp.Acta F
Crystal structure of a soluble cleaved HIV-1 envelope trimer2013Julien, JP., et al.Science
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp1202013Kong, L., et al.Nat. Struct. Mol. Biol
Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP332012Kong, L., et al.Journal of Virology